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Bis(methylthio)gliotoxin (FR-49175) (CAS 74149-38-5)

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Application:An antiphagocytic metabolite
CAS Number:74149-38-5
Molecular Weight:356.5
Molecular Formula:C15H20N2O4S2
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Bis(methylthio)gliotoxin (FR-49175) sc-201027 1 mg $86
Bis(methylthio)gliotoxin (FR-49175) sc-201027A 5 mg $341
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, reported to Inhibit PAF-induced bronchoconstriction.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (25 mg/ml), ethanol (25 mg/ml), and water (Partly miscible).
Storage:Store at -20° C
Melting Point:70° C
Boiling Point:669.62° C at 760 mmHg (Predicted)
Density:1.50 g/cm3 (Predicted)
Refractive Index:n20D 1.70
IC50:P388 cells : IC50 = 110 nM (mouse); HUVEC50: IC50 = 1120 nM (human); PAF: IC50 = 8400 nM; PAF-induced platelet aggregation: IC50 = 8.4 µM; collagen-induced aggregation: IC50 = 84.2 µM
pK Values:pKa: 12.7 (Predicted)
Safety and Reference Information
Transport:UN 3462, Class 6.1, Packing group III
WGK Germany:3
PubChem CID:194564
MDL Number:MFCD00133146
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Bis(methylthio)gliotoxin (FR-49175) Product Reviews

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1. Pahl, H.L., et al. 1996. J. Exp. Med. 183: 1829-1840. PMID: 8666939
2. Bonin, F., et al. 2004. J. Biol. Chem. 279: 52425-52436. PMID: 15456758
3. Zhao, W.Y., et al. 2009. Nat. Prod. Res. 23: 203-207. PMID: 19235019
Bis(methylthio)gliotoxin (FR-49175) (CAS 74149-38-5) Product Citations
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