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ITSA1 (CAS 200626-61-5)

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Application:An HDAC activator via TSA suppression
CAS Number:200626-61-5
Purity:98%
Molecular Weight:292.12
Molecular Formula:C13H7Cl2N3O
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
ITSA1 sc-200894 25 mg $78
ITSA1 sc-200894A 100 mg $222
Description
ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. TSA (Trichostatin A) is an inhibitor of histone deacetylase. ITSA1 was found to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation.
Technical Information
Appearance:White
Physical State:Solid
Solubility:Soluble in DMSO (25 mg/mL).
Storage:Store at room temperature
Melting Point:172.79 °C
Boiling Point:483.41 °C at 760 mmHg
Density:1.52 g/cm3
Refractive Index:n20D 1.71
Safety and Reference Information
WGK Germany:3
PubChem CID:771910
MDL Number:MFCD00195103
SMILES:C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Haggarty, S.J., et al. 2003. Chem. Biol. 10: 1267-1279. PMID: 14700634
2. Koeller, K.M., et al. 2003. Chem. Biol. 10: 397-410. PMID: 12770822
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