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Geranylgeraniol (CAS 24034-73-9)

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Synonym:Tetraprenol; all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol
Application:An intermediate in the mevalonate pathway
CAS Number:24034-73-9
Purity:95%
Molecular Weight:290.48
Molecular Formula:C20H34O
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Geranylgeraniol sc-200858 20 mg $79
Geranylgeraniol sc-200858A 100 mg $312
Description
Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro When working with statins, geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells.
Technical Information
Appearance:Neat oil
Physical State:Liquid
Solubility:Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), chloroform, dichloromethane, ethyl acetate, hexane, ether, and acetone.
Storage:Store at -80° C
Boiling Point:397.07 °C at 760 mmHg (Predicted)
Density:0.88 g/mL
Refractive Index:n20D 1.49
Safety and Reference Information
WGK Germany:3
PubChem CID:5281365
MDL Number:MFCD00129083
Beilstein Registry:1913779
SMILES:CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CO)/C)/C)/C)C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Aiuchi, T., et al. 1998. J. Biochem. 124: 300-303. PMID: 9685718
2. Fisher, J.E., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 133-138. PMID: 9874784
3. Montero, M.T., et al. 2004. J. Immunol. 173: 4936-4944. PMID: 15470035
4. Campia, I., et al. 2009. Br. J. Pharmacol. 158: 1777-1786. PMID: 19888963
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