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TEMPOL (CAS 2226-96-2)

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Synonym:1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
Application:A superoxide dismutase mimetic that restores the effects of TNF-α
CAS Number:2226-96-2
Purity:≥99%
Molecular Weight:172.2
Molecular Formula:C9H18NO2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
TEMPOL sc-200825 1 g $26
Description
TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.
Technical Information
Appearance:Crystalline
Physical State:Solid
Solubility:Soluble in water (1670 g/l) at 20 °C, ethanol (100 mM), methanol, and DMSO (100 mM).
Storage:Store at room temperature
Melting Point:69-71 °C (lit.)
Boiling Point:269 °C
Density:1.19 g/cm3
IC50:Plasmodium falciparum K1: IC50 = 19 µg/ml; Plasmodium falciparum NF54: IC50 = 27 µg/ml
pK Values:pKb: 5.15
Safety and Reference Information
WGK Germany:1
RTECS:TN8991000
PubChem CID:137994
Merck Index:14: 9141
MDL Number:MFCD00006478
EC Number:218-760-9
Beilstein Registry:1422990
SMILES:CC1(CC(CC(N1[O])(C)C)O)C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Mitchell, J.B., et al. 1991. Arch. Biochem. Biophys. 289: 62-70. PMID: 1654848
2. Xu, H., et al. 2004. Hypertension. 43: 329-334. PMID: 14707156
3. Khattab, M.M., 2006. Eur. J. Pharmacol. 548: 167-173. PMID: 16973155
4. Lipman, T., et al. 2006. Eur. J. Pharmacol. 549: 50-57. PMID: 16989807
5. Mariappan, N., et al. 2007. Am. J. Physiol. Heart Circ. Physiol. 293: H2726-H2737. PMID: 17675574
6. Pires, P.W., et al. 2010. Microvasc Res. PMID: 20600163
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