Molecular structure of TEMPOL, CAS Number: 2226-96-2
TEMPOL (CAS 2226-96-2)
See product citations (33)
Alternate Names:
4-OH-TEMPO;4-Hydroxy-TEMPO;4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxy, free radical
Application:
TEMPOL is a superoxide dismutase mimetic that restores the effects of TNF-α
CAS Number:
2226-96-2
Purity:
≥99%
Molecular Weight:
172.25
Molecular Formula:
C9H18NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL may act to restore the oxidative stress and cardiac dysfunction induced by TNF-alpha and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.
TEMPOL (CAS 2226-96-2) References
- Tempol lowers blood pressure and sympathetic nerve activity but not vascular O2- in DOCA-salt rats. | Xu, H., et al. 2004. Hypertension. 43: 329-34. PMID: 14707156
- Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol. | Mitchell, JB., et al. 1991. Arch Biochem Biophys. 289: 62-70. PMID: 1654848
- TEMPOL, a membrane-permeable radical scavenger, attenuates peroxynitrite- and superoxide anion-enhanced carrageenan-induced paw edema and hyperalgesia: a key role for superoxide anion. | Khattab, MM. 2006. Eur J Pharmacol. 548: 167-73. PMID: 16973155
- Neuroprotective effects of the stable nitroxide compound Tempol on 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells. | Lipman, T., et al. 2006. Eur J Pharmacol. 549: 50-7. PMID: 16989807
- TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol. | Mariappan, N., et al. 2007. Am J Physiol Heart Circ Physiol. 293: H2726-37. PMID: 17675574
- Tempol, a superoxide dismutase mimetic, prevents cerebral vessel remodeling in hypertensive rats. | Pires, PW., et al. 2010. Microvasc Res. 80: 445-52. PMID: 20600163
- Tempol prevents chronic sleep-deprivation induced memory impairment. | Alzoubi, KH., et al. 2016. Brain Res Bull. 120: 144-50. PMID: 26616531
- Tempol prevents post-traumatic stress disorder induced memory impairment. | Alzoubi, KH., et al. 2018. Physiol Behav. 184: 189-195. PMID: 29217357
- Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats. | Shateri, H., et al. 2019. Life Sci. 221: 65-71. PMID: 30738867
- Tempol treatment shows phenotype improvement in mdx mice. | Hermes, TA., et al. 2019. PLoS One. 14: e0215590. PMID: 31009514
- Tempol improves redox status in mdx dystrophic diaphragm muscle. | Hermes, TA., et al. 2020. Int J Exp Pathol. 101: 289-297. PMID: 33098599
- Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. | Li, T., et al. 2021. Redox Biol. 41: 101886. PMID: 33592539
- The antioxidant tempol transforms gut microbiome to resist obesity in female C3H mice fed a high fat diet. | Choudhuri, R., et al. 2022. Free Radic Biol Med. 178: 380-390. PMID: 34883252
- Effect of tempol and straw size on rooster sperm quality and fertility after post-thawing. | Najafi, A., et al. 2022. Sci Rep. 12: 12192. PMID: 35842559
- Tempol Inhibits the Growth of Lung Cancer and Normal Cells through Apoptosis Accompanied by Increased O2•- Levels and Glutathione Depletion. | Park, WH. 2022. Molecules. 27: PMID: 36364165
Inhibitor of:
C10orf88, Ces1a, DEPP, GrpEL2, GTPBP3, MPV17L, Nitrotyrosine, Oxr1, PTCD3, PYROXD1, Romo1, SATB1, TRF, and ZFR.Activator of:
NOXO1, p22-phox, and UQCRHL.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TEMPOL, 1 g | sc-200825 | 1 g | $38.00 |