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Troleandomycin (CAS 2751-09-9)

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Synonym:Triacetyloleandomycinum
Application:A macrolide antibiotic and an inhibitor of CYP
CAS Number:2751-09-9
Purity:98%
Molecular Weight:813.97
Molecular Formula:C41H67NO15
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Troleandomycin sc-200747 10 mg $85
Troleandomycin sc-200747A 50 mg $344
Description
Troleandomycin is a macrolide antibiotic. The compound is a stronger inhibitor of cytochrome P450 (P450 or CYP)-dependent drug oxidation) when compared to Roxithromycin (sc-205845). Cytochrome P450 has been shown to be involved in oxidizing N omega-hydroxy-L-arginine through NADPH and O2 to nitric oxide and citrulline. Research shows that Troleandomycin inhibits the release of nitric oxide from Glycerol trinitrate (GTN). Troleandomycin has been used in multiple asthma studies.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (50 mg/mL) and ethanol (25 mg/mL)
Storage:Store at room temperature
Safety and Reference Information
WGK Germany:2
RTECS:RJ9900000
PubChem CID:17675
Merck Index:13,9839
MDL Number:MFCD00871198
EC Number:220-392-9
Beilstein Registry:1418238
SMILES:C[C@@H]1C[C@@H]([C@H]([C@@H](O1)O[C@H]2[C@H](C[C@@]3(CO3)C(=O)[C@@H]([C@@H]( [C@H]([C@H](OC(=O)[C@@H]([C@H]([C@@H]2C)O[C@H]4C[C@@H]([C@H]([C@@H](O4)C)OC( =O)C)OC)C)C)C)OC(=O)C)C)C)OC(=O)C)N(C)C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Weinberger, M., et al. 1977. J. Allergy Clin. Immunol. 59: 228-231. PMID: 300083
2. Zeiger, R.S., et al. 1980. J. Allergy Clin. Immunol. 66: 438-446. PMID: 6968762
3. Ludden, T.M. 1985. Clin Pharmacokinet. 10: 63-79. PMID: 3882305
4. Pollock, J.S., et al. 1993. Am. J. Physiol. 265: C1379-C1387. PMID: 7694497
5. Kozlov, A.V., et al. 2003. Br. J. Pharmacol. 139: 989-997. PMID: 12839873
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