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Triciribine (CAS 35943-35-2)

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Synonym:API-2; NSC 154020; Tricyclic Nucleoside; Akt/PKB Signaling Inhibitor-2
Application:A tricyclic nucleoside that induces apoptosis and has antineoplastic and antiviral activity
CAS Number:35943-35-2
Molecular Weight:320.30
Molecular Formula:C13H16N6O4
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Triciribine sc-200661 1 mg $100
Triciribine sc-200661A 5 mg $180
Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt. Akt kinase inhibition has been shown to induce apoptosis and cell growth in cancer cell research. Triciribine can selectively inhibit Akt1, Akt2, and Akt3 without inhibiting known upstream activators,PDK1 and PI 3-Kinase, of Akt. Studies show that Triciribine in duces apoptosis and inhibits cell growth in cells that express atypical Akt1. Additionally, Triciribine has antineoplastic and antiviral activity at low micromolar and submicromolar concentrations, and has been demonstrated to inhibit incorporation of amino acids into proteins and purine nucleotide synthesis.
Technical Information
Physical State:Solid
Solubility:Soluble in 1eq. HCl (100 mM), and DMSO (100 mM).
Storage:Store at -20° C
Melting Point:216.02° C (Predicted)
Boiling Point:~718.49° C at 760 mmHg (Predicted)
Density:2.03 g/cm3 (Predicted)
Refractive Index:n20D 1.93 (Predicted)
Safety and Reference Information
PubChem CID:65399
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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. Moore, E.C., et al. 1989. Biochem. Pharmacol. 38: 4037-4044. PMID: 2480791
2. Porcari, A.R., et al. 2000. J. Med. Chem. 43: 2438-2448. PMID: 10882371
3. Yang, L., et al. 2004. Cancer Res. 64: 4394-4399. PMID: 15231645
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