Wedelolactone (CAS 524-12-9)
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Wedelolactone is a coumestan that has gained attention in the field of research for its diverse biological activities. It is frequently used as a tool to study signaling pathways due to its ability to inhibit 5-lipoxygenase and the IKK complex, which are involved in the synthesis of leukotrienes and the activation of NF-κB, respectively. By modulating these pathways, wedelolactone is instrumental in dissecting the cellular responses to inflammatory stimuli and the regulation of genes involved in inflammation and immunity. Additionally, its role as a potent inhibitor of the DNA damage response kinase DNA-PK has made it valuable in the study of cellular responses to DNA damage and repair mechanisms. Researchers also employ wedelolactone to explore its potential effects on estrogen receptors, contributing to the understanding of hormone-mediated signaling.
Wedelolactone (CAS 524-12-9) References
- Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. | Syed, SD., et al. 2003. Phytother Res. 17: 420-1. PMID: 12722155
- Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. | Kobori, M., et al. 2004. Cell Death Differ. 11: 123-30. PMID: 14526390
- Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2. | Xia, Y., et al. 2013. Eur J Pharmacol. 714: 105-11. PMID: 23791612
- Wedelolactone and coumestan derivatives as new antihepatotoxic and antiphlogistic principles. | Wong, SM., et al. 1988. Arzneimittelforschung. 38: 661-5. PMID: 2458108
- Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. | Liu, YQ., et al. 2016. Sci Rep. 6: 32260. PMID: 27558652
- Wedelolactone Enhances Osteoblastogenesis but Inhibits Osteoclastogenesis through Sema3A/NRP1/PlexinA1 Pathway. | Liu, YQ., et al. 2016. Front Pharmacol. 7: 375. PMID: 27803667
- Wedelolactone from Vietnamese Eclipta prostrata (L) L. Protected Zymosan-induced shock in Mice. | Cuong, TT., et al. 2018. Iran J Pharm Res. 17: 653-660. PMID: 29881422
- Wedelolactone suppresses IL-1β maturation and neutrophil infiltration in Aspergillus fumigatus keratitis. | Cheng, M., et al. 2019. Int Immunopharmacol. 73: 17-22. PMID: 31078922
- Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway. | Hassanein, EHM., et al. 2020. Oxid Med Cell Longev. 2020: 1675957. PMID: 32377290
- Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis. | Pan, H., et al. 2020. Cell Prolif. 53: e12868. PMID: 32656909
- Anti-inflammatory effect of wedelolactone on DSS induced colitis in rats: IL-6/STAT3 signaling pathway. | Prakash, T. and Janadri, S. 2022. J Ayurveda Integr Med. 100544. PMID: 35337710
- Wedelolactone Promotes the Chondrogenic Differentiation of Mesenchymal Stem Cells by Suppressing EZH2. | Qin, W., et al. 2022. Int J Stem Cells.. PMID: 36310024
- Ability of wedelolactone, heparin, and para-bromophenacyl bromide to antagonize the myotoxic effects of two crotaline venoms and their PLA2 myotoxins. | Melo, PA. and Ownby, CL. 1999. Toxicon. 37: 199-215. PMID: 9920492
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wedelolactone, 1 mg | sc-200648 | 1 mg | $108.00 | |||
Wedelolactone, 5 mg | sc-200648A | 5 mg | $330.00 |