Bestatin hydrochloride (CAS 65391-42-6)

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Application:	An inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase
CAS Number:	65391-42-6
Purity:	99%
Molecular Weight:	344.83
Molecular Formula:	C₁₆H₂₄N₂O₄ HCl

Ordering Information

Product Name	Catalog #	Unit	Price
Bestatin hydrochloride	sc-200564	5 mg	$70
Bestatin hydrochloride	sc-200564A	25 mg	$282
Bestatin hydrochloride	sc-200564B	500 mg	$620

Description

Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, CD13 (Aminopeptidase M), and LAP3 (leucine aminopeptidase). Inhibition of these proteins by Bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.

Technical Information

Appearance:	Solid
Physical State:	Solid
Solubility:	Soluble in water (4 mg/ml,warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
Storage:	Store at -20° C
Melting Point:	216-218 °C
Boiling Point:	620.8 °C at 760 mmHg

Safety and Reference Information

WGK Germany:	3
PubChem CID:	6455125
MDL Number:	MFCD00058004
Beilstein Registry:	4628066
SMILES:	CC(C)C[C@@](C(=O)[C@H]([C@@H](CC1=CC=CC=C1)N)O)(C(=O)O)N.Cl

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Rich, D.H., et al. 1984. J. Med. Chem. 27: 417-422. PMID: 6142952
2. Wilkes, S.H. and Prescott, J.M. 1985. J. Biol. Chem. 260: 13154-13162. PMID: 2865258
3. Orning, L., et al. 1991. J. Biol. Chem. 266: 1375-1378. PMID: 1846352
4. Taylor, A. 1993. FASEB J. 7: 290-298. PMID: 8440407

SDS

Datasheet/SDS