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Phenidone (CAS 92-43-3)

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Application:A dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor
CAS Number:92-43-3
Molecular Weight:162.2
Molecular Formula:C9H10N2O
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Phenidone sc-200508 5 g $30
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Studies indicate that Phenidone decreases the oxidative affects of xanthine/xanthine oxidase, Hydrogen Peroxide (sc-203336), Arachidonic Acid(sc-200770), and Fe2+ ascorbic acid. Mouse cortical research reports that Phenidone weakens oxygen/glucose deprivation-induced neurotoxicity through apoptotic and antioxidant action. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.
Technical Information
Appearance:Crystalline powder
Physical State:Solid
Solubility:Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol (25 mg/mL).
Storage:Store at room temperature
Melting Point:122-123 °C
Boiling Point:304.1 °C at 760 mmHg
Density:1.19 g/cm3
Refractive Index:n20D 1.58
IC50:Dual lipoxygenase: IC50 = 24 µM; cyclooxygenase : IC50 = 11.8 µM
pK Values:pKa: 9.5
Safety and Reference Information
Transport:UN 2811, Class 6.1, Packing group III
WGK Germany:2
PubChem CID:7090
Merck Index:14: 7309
MDL Number:MFCD00003094
EC Number:202-155-1
Beilstein Registry:131856
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Wie, M.B., et al. 1999. Neurosci. Lett. 272: 91-94. PMID: 10507549
2. Kim, H.C., et al. 2000. Brain Res. 874: 15-23. PMID: 10936219
3. Moon, C., et al. 2005. Brain Res. 1035: 206-210. PMID: 15722060
4. Cusan, C., et al. 2006. Curr Drug Discov Technol. 3: 67-73. PMID: 16712464
5. Li, Z., et al. 2008. Neurosci. Lett. 445: 1-6. PMID: 18760329
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