Molecular structure of Proadifen hydrochloride, CAS Number: 62-68-0
Proadifen hydrochloride (CAS 62-68-0)
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Alternate Names:
2-(diethylamino)ethyl 2,2-diphenylpentanoate hydrochloride; Propyladiphenin; SKF-525A HCl
Application:
Proadifen hydrochloride is an inhibitor of NOS1, AChR, cytochrome P-450, and KIR6.1
CAS Number:
62-68-0
Molecular Weight:
389.96
Molecular Formula:
C23H31NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Proadifen hydrochloride also known as SKF-525A HCl has many biochemical functions, some of which include: inhibitory effects on NOS1 (neuronal nitric oxide synthase IC50 = 90 mM), adult mouse skeletal muscle AChR (acetyl choline receptor), hepatic drug metabolism via the CYP (cytochrome P450) system, CYP-dependent (cytochrome P450-dependent) arachidonate metabolism (90% at 50 muM), transmembrane calcium influx, and platelet thromboxane synthesis. This compound has also been shown to block KIR6.1 (ATP-sensitive inward rectifier potassium channel 8 IC50 = 4.4 mM) and stimulate endothelial cell prostacyclin production.
Proadifen hydrochloride (CAS 62-68-0) References
- Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries. | Kauser, K., et al. 1991. Circ Res. 68: 1154-63. PMID: 1901255
- The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. | Spitzmaul, G., et al. 2009. Br J Pharmacol. 157: 804-17. PMID: 19422391
- Investigation of the antimuscarinic and other actions of proadifen in-vitro. | Choo, LK., et al. 1986. J Pharm Pharmacol. 38: 898-901. PMID: 2880963
- Cytochrome P450-dependent arachidonate metabolism in renomedullary cells: formation of Na+K+-ATPase inhibitor. | Carroll, MA., et al. 1986. J Hypertens Suppl. 4: S33-42. PMID: 3021941
- Prostacyclin-stimulating drugs: new prospects. | Boeynaems, JM., et al. 1986. Prostaglandins. 32: 145-9. PMID: 3532206
- Inhibition of mitochondrial oxidative metabolism by SKF-525A in intact cells and isolated mitochondria. | Galeotti, T., et al. 1983. Biochem Pharmacol. 32: 3285-95. PMID: 6651857
- Stereoselective and calcium-dependent contractile effects of narcotic antagonist analgesics in the vascular smooth muscle of the rat. | Lee, CH. and Berkowitz, BA. 1976. J Pharmacol Exp Ther. 198: 347-56. PMID: 7664
- Molecular mechanisms of dibromoalkane cytotoxicity in isolated rat hepatocytes. | Khan, S., et al. 1993. Biochem Pharmacol. 45: 439-47. PMID: 8435094
- The role of nephrectomy and proadifen in blood pressure homeostasis following an acute kinin-induced hypotension in normotensive rats. | Holte, HR. and Berg, T. 1996. Br J Pharmacol. 117: 1516-20. PMID: 8730748
Inhibitor of:
11β-HSD2, AChR, c-Erb-A β-1, CYP, Cyp2c29, Cyp2c37, CYP4Z1, NCB5OR, NOS1, and SULT2A3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Proadifen hydrochloride, 250 mg | sc-200492 | 250 mg | $144.00 | |||
Proadifen hydrochloride, 1 g | sc-200492A | 1 g | $421.00 |