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cyclin D1 Antibody (DCS-6): sc-20044

 |  Datasheet

(Based on data analysis)

  • cyclin D1 Antibody (DCS-6) is a mouse monoclonal IgG2a provided at 200 µg/ml
  • raised against recombinant full length human protein
  • recommended for detection of cyclin D1 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA
  • fluorescein (sc-20044 FITC) and phycoerythrin (sc-20044 PE) conjugates for intracellular FCM, 100 tests
  • Alexa Fluor® 405(sc-20044 AF405), Alexa Fluor® 488 (sc-20044 AF488) and Alexa Fluor® 647 (sc-20044 AF647) conjugates for FCM or immunofluorescence; 100 µg/2 ml
  • See 73 citations for cyclin D1 Antibody (DCS-6)
 

See additional Cyclin Antibodies including Cyclin, B-like cyclin, cyclin A, cyclin A-type, cyclin A1, cyclin B, cyclin B1, cyclin C, cyclin D, cyclin D1, cyclin delta-3, cyclin E, cyclin F, cyclin G1, cyclin H, cyclin I, cyclin J, cyclin K, cyclin L1, cyclin M1, cyclin O, cyclin T1, cyclin Y, cyclin YL1, cyclin YL3 , cyclin 2, cyclin A2, cyclin B2, cyclin D2, cyclin E2, cyclin G2, cyclin L2, cyclin M2, cyclin T2, cyclin YL2, cyclin 3, cyclin B3, cyclin D3, cyclin M3 and cyclin M4.

Also see chemical cyclin D1 Inhibitors for functional analysis of cellular responses to cyclin D1.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   FCM   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
cyclin D1 Antibody (DCS-6) sc-20044 200 µg/ml $279
cyclin D1 Antibody (DCS-6) Alexa Fluor® 405 sc-20044 AF405 100 µg/2 ml $314
cyclin D1 Antibody (DCS-6) Alexa Fluor® 488 sc-20044 AF488 100 µg/2 ml $314
cyclin D1 Antibody (DCS-6) Alexa Fluor® 647 sc-20044 AF647 100 µg/2 ml $314
cyclin D1 Antibody (DCS-6) FITC sc-20044 FITC 100 tests in 2 ml $292
cyclin D1 Antibody (DCS-6) PE sc-20044 PE 100 tests in 2 ml $303
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
cyclin D1 CRISPR/Cas9 KO Plasmid (m) sc-419509 20 µg $345
cyclin D1 HDR Plasmid (m) sc-419509-HDR 20 µg $385
cyclin D1 CRISPR/Cas9 KO Plasmid (h) sc-400047 20 µg $345
cyclin D1 HDR Plasmid (h) sc-400047-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
cyclin D1 siRNA (h) sc-29286 10 µM $258
cyclin D1 siRNA (m) sc-29287 10 µM $258
cyclin D1 siRNA (h2) sc-44257 10 µM $258
cyclin D1 (h)-PR sc-29286-PR 10 µM, 20 µl $23
cyclin D1 (m)-PR sc-29287-PR 10 µM, 20 µl $23
cyclin D1 (h2)-PR sc-44257-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
cyclin D1 shRNA Plasmid (h) sc-29286-SH 20 µg $520
cyclin D1 shRNA Plasmid (m) sc-29287-SH 20 µg $520
cyclin D1 shRNA Plasmid (h2) sc-44257-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
cyclin D1 shRNA (h) Lentiviral Particles sc-29286-V 200 µl $625
cyclin D1 shRNA (m) Lentiviral Particles sc-29287-V 200 µl $625
cyclin D1 shRNA (h2) Lentiviral Particles sc-44257-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
C32 nuclear extract sc-2136 250 µg/0.05 ml $143
KNRK nuclear extract sc-2141 250 µg/0.05 ml $143
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CCND1 595 11q13.2 NM_053056 P24385
254500
Mouse Ccnd1 12443 7 F5 P25322
N/A
 


The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.

cyclin D1 Antibody (DCS-6) Product Citations
See how others have used cyclin D1 Antibody (DCS-6) and or cyclin D1 Antibody (DCS-6) conjugates.


73 total citations
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cyclin D1 Antibody (DCS-6) Data
Click on image to enlarge
cyclin D1 (DCS-6): sc-20044. Western blot analysis of cyclin D1 expression in C32 (A) and KNRK (B) nuclear extracts.
cyclin D1 (DCS-6) Alexa Fluor 488: sc-20044 AF488. Intracellular FCM analysis of fixed and permeabilized Jurkat cells. Black line histogram represents the isotype control, normal mouse IgG2a: sc-3891.
cyclin D1 (DCS-6): sc-20044. Immunofluorescence staining of methanol-fixed KNRK cells showing mostly nuclear localization.
cyclin D1 (DCS-6): sc-20044. Western blot analysis of cyclin D1 expression in RAW 264.7 whole cell lysate.
cyclin D1 (DCS-6) FITC: sc-20044 FITC. Intracellular FCM analysis of fixed and permeabilized KNRK cells. Black line histogram represents the isotype control, normal mouse IgG2a: sc-2856.
cyclin D1 (DCS-6) PE: sc-20044 PE. Intracellular FCM analysis of fixed and permeabilized Jurkat cells. Black line histogram represents the isotype control, normal mouse IgG2a: sc-2867.
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