cyclin D1 Antibody (DCS-6): sc-20044
- cyclin D1 Antibody (DCS-6) is a mouse monoclonal IgG2a κ, cited in 453 publications, provided at 200 µg/ml
- Anti-cyclin D1 Antibody (DCS-6) is recommended for detection of cyclin D1 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA
- cyclin D1 Antibody (DCS-6) is available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin D1 Antibody (DCS-6) for WB and IHC(P) applications. These reagents are now offered in bundles with cyclin D1 Antibody (DCS-6) (see ordering information below).
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cyclin D1 Antibody (DCS-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects cyclin D1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). cyclin D1 Antibody (DCS-6) is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. cyclin D1 plays a pivotal role in cell cycle regulation, particularly in the transition from G1 phase to S phase, where cyclin D1 is essential for cell progression into DNA synthesis. This regulation is crucial because improper control of the cell cycle can lead to uncontrolled cell proliferation, a hallmark of cancer. cyclin D1 interacts with cyclin-dependent kinases (CDKs) to phosphorylate the retinoblastoma protein, which releases E2F transcription factors that drive the expression of genes necessary for S phase entry. Dysregulation of cyclin D1 has been implicated in various malignancies, making cyclin D1 a significant focus of cancer research. Understanding cyclin D1 function and regulation is vital for developing targeted therapies and improving cancer treatment outcomes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cyclin D1 Antibody (DCS-6) References:
- Cloning of a D-type cyclin from murine erythroleukemia cells. | Kiyokawa, H., et al. 1992. Proc Natl Acad Sci U S A. 89: 2444-7. PMID: 1372445
- Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene. | Motokura, T., et al. 1992. J Biol Chem. 267: 20412-5. PMID: 1383201
- Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. | Inaba, T., et al. 1992. Genomics. 13: 565-74. PMID: 1386335
- Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. | Xiong, Y., et al. 1992. Genomics. 13: 575-84. PMID: 1386336
- Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. | Won, KA., et al. 1992. Proc Natl Acad Sci U S A. 89: 9910-4. PMID: 1409718
- Human D-type cyclin. | Xiong, Y., et al. 1991. Cell. 65: 691-9. PMID: 1827756
- Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. | Draetta, G. 1990. Trends Biochem Sci. 15: 378-83. PMID: 2147521
- Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. | Ewen, ME., et al. 1993. Cell. 73: 487-97. PMID: 8343202
- Physical interaction of the retinoblastoma protein with human D cyclins. | Dowdy, SF., et al. 1993. Cell. 73: 499-511. PMID: 8490963
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cyclin D1 Antibody (DCS-6) | sc-20044 | 200 µg/ml | $322.00 | |||
cyclin D1 Antibody (DCS-6): m-IgG Fc BP-HRP Bundle | sc-528355 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin D1 Antibody (DCS-6): m-IgGκ BP-HRP Bundle | sc-520714 | 200 µg Ab, 40 µg BP | $361.00 | |||
cyclin D1 Antibody (DCS-6): m-IgG2a BP-HRP Bundle | sc-547075 | 200 µg Ab; 10 µg BP | $361.00 | |||
cyclin D1 Antibody (DCS-6) FITC | sc-20044 FITC | 200 µg/ml | $336.00 | |||
cyclin D1 Antibody (DCS-6) PE | sc-20044 PE | 200 µg/ml | $349.00 | |||
cyclin D1 Antibody (DCS-6) Alexa Fluor® 488 | sc-20044 AF488 | 200 µg/ml | $364.00 | |||
cyclin D1 Antibody (DCS-6) Alexa Fluor® 546 | sc-20044 AF546 | 200 µg/ml | $364.00 | |||
cyclin D1 Antibody (DCS-6) Alexa Fluor® 594 | sc-20044 AF594 | 200 µg/ml | $364.00 | |||
cyclin D1 Antibody (DCS-6) Alexa Fluor® 647 | sc-20044 AF647 | 200 µg/ml | $364.00 | |||
cyclin D1 Antibody (DCS-6) Alexa Fluor® 680 | sc-20044 AF680 | 200 µg/ml | $364.00 | |||
cyclin D1 Antibody (DCS-6) Alexa Fluor® 790 | sc-20044 AF790 | 200 µg/ml | $364.00 |