Molecular structure of S-Nitrosoglutathione (GSNO), CAS Number: 57564-91-7
S-Nitrosoglutathione (GSNO) (CAS 57564-91-7)
See product citations (15)
Alternate Names:
S-Nitrosoglutathione (GSNO) is also known as SNOG, and N- (N-L-γ-glutamyl-S-nitroso-L-cysteinyl)-glycine.
Application:
S-Nitrosoglutathione (GSNO) is a spontaneously releasing nitric oxide donor which inhibits NFκB and platelet activation
CAS Number:
57564-91-7
Purity:
≥98%
Molecular Weight:
336.32
Molecular Formula:
C10H16N4O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-Nitrosoglutathione (GSNO) is an amino acid nitric oxide donor, when under physiological conditions spontaneously releases nitric oxide. In research, S-Nitrosoglutathione (GSNO) has been observed to selectively inhibit platelet activation and display cardioprotective effects. S-Nitrosoglutathione (GSNO) also inhibits NF-kappaB activation, endothelial cell proliferation and cathepsin B (cysteine proteases). GNSO has demonstrated dose dependent effects on Thymocytes by inducing apoptosis in T cells in low concentrations (< 0.6 mM), while protecting T cells from apoptosis in higher concentrations (1-2 mM).
S-Nitrosoglutathione (GSNO) (CAS 57564-91-7) References
- Inhibition of cysteine protease activity by NO-donors. | Ascenzi, P., et al. 2001. Curr Protein Pept Sci. 2: 137-53. PMID: 12370021
- Arsenic triggers the nitric oxide (NO) and S-nitrosoglutathione (GSNO) metabolism in Arabidopsis. | Leterrier, M., et al. 2012. Environ Pollut. 166: 136-43. PMID: 22504427
- Protective role of S-nitrosoglutathione (GSNO) against cognitive impairment in rat model of chronic cerebral hypoperfusion. | Won, JS., et al. 2013. J Alzheimers Dis. 34: 621-35. PMID: 23254638
- UPLC-MS/MS measurement of S-nitrosoglutathione (GSNO) in human plasma solves the S-nitrosothiol concentration enigma. | Tsikas, D., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 927: 147-57. PMID: 23453822
- Current overview of S-nitrosoglutathione (GSNO) in higher plants. | Corpas, FJ., et al. 2013. Front Plant Sci. 4: 126. PMID: 23658557
- Mechanisms and targets of the modulatory action of S-nitrosoglutathione (GSNO) on inflammatory cytokines expression. | Corti, A., et al. 2014. Arch Biochem Biophys. 562: 80-91. PMID: 25135357
- The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy. | Barnett, SD. and Buxton, ILO. 2017. Crit Rev Biochem Mol Biol. 52: 340-354. PMID: 28393572
- Osteoimmune Modulation and Guided Osteogenesis Promoted by Barrier Membranes Incorporated with S-Nitrosoglutathione (GSNO) and Mesenchymal Stem Cell-Derived Exosomes. | Wang, X., et al. 2020. Int J Nanomedicine. 15: 3483-3496. PMID: 32523344
- S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide. | Konorev, EA., et al. 1995. J Pharmacol Exp Ther. 274: 200-6. PMID: 7616400
- Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells. | Peng, HB., et al. 1995. J Biol Chem. 270: 17050-5. PMID: 7622526
- Nitric oxide inhibition of endothelial cell mitogenesis and proliferation. | Sarkar, R., et al. 1995. Surgery. 118: 274-9. PMID: 7638744
- Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. | Peng, HB., et al. 1995. J Biol Chem. 270: 14214-9. PMID: 7775482
- Biological activity of S-nitrosothiols: the role of nitric oxide. | Mathews, WR. and Kerr, SW. 1993. J Pharmacol Exp Ther. 267: 1529-37. PMID: 7903392
- Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation. | de Belder, AJ., et al. 1994. Cardiovasc Res. 28: 691-4. PMID: 8025915
- The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis. | Sandau, K. and Brüne, B. 1996. Cell Signal. 8: 173-7. PMID: 8736700
Inhibitor of:
cathepsin B.Activator of:
CHCHD5, CXorf58, Dexras1, Dexras2, EG632778, Gamma-glutamyltransferase (GGT), MAAI, NDUFA12, NDUFB2, NDUFC1, R-ras3, Rab 40A, SREBP-2, T-cadherin, and TMEM209.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-Nitrosoglutathione (GSNO), 10 mg | sc-200349 | 10 mg | $85.00 | |||
S-Nitrosoglutathione (GSNO), 25 mg | sc-200349B | 25 mg | $206.00 | |||
S-Nitrosoglutathione (GSNO), 50 mg | sc-200349A | 50 mg | $339.00 | |||
S-Nitrosoglutathione (GSNO), 100 mg | sc-200349C | 100 mg | $449.00 |