Molecular structure of (±)-S-Nitroso-N-acetylpenicillamine, CAS Number: 79032-48-7
(±)-S-Nitroso-N-acetylpenicillamine (CAS 79032-48-7)
See product citations (18)
Alternate Names:
(±)-S-Nitroso-N-acetylpenicillamine also known as S-Nitroso-N-acetyl-DL-penicillamine; SNAP;N-Acetyl-3-(nitrosothio)-DL-valine; (±)-S-nitroso-N-acetylpenicillamine; C7-H12-N2-O4-S; penicillamine, (±)-S-nitroso-N-acetyl-
Application:
(±)-S-Nitroso-N-acetylpenicillamine is a cysteine protease inhibitor and spontaneous NO donor in physiological conditions
CAS Number:
79032-48-7
Purity:
≥98%
Molecular Weight:
220.25
Molecular Formula:
C7H12N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
(±)-S-Nitroso-N-acetylpenicillamine is a research chemical of interest due to its role as a nitric oxide (NO) donor. In biochemical studies, it is used to mimic the effects of endogenous NO, enabling researchers to investigate the diverse physiological roles of this gaseous signaling molecule. (±)-S-Nitroso-N-acetylpenicillamine is utilized in the examination of signal transduction pathways that are modulated by NO, such as those affecting platelet function and neurotransmission. The compound′s ability to release NO in a controlled manner makes it valuable in understanding the mechanisms of NO-related cellular processes and in the study of the molecular basis of conditions where NO signaling is disrupted.
(±)-S-Nitroso-N-acetylpenicillamine (CAS 79032-48-7) References
- Synthesis and cytotoxicities of mannose conjugated S-nitroso-N-acetylpenicillamine (SNAP). | Wu, X., et al. 2002. Bioorg Med Chem. 10: 2303-7. PMID: 11983528
- Inhibition of cysteine protease activity by NO-donors. | Ascenzi, P., et al. 2001. Curr Protein Pept Sci. 2: 137-53. PMID: 12370021
- Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. | Hogg, N., et al. 1992. Biochem J. 281 (Pt 2): 419-24. PMID: 1310595
- Lack of tolerance to a 24-hour infusion of S-nitroso N-acetylpenicillamine (SNAP) in conscious rabbits. | Shaffer, JE., et al. 1992. J Pharmacol Exp Ther. 260: 286-93. PMID: 1731043
- Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation. | Park, YK., et al. 2008. Mol Pharmacol. 74: 236-45. PMID: 18426857
- Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. | Garg, UC. and Hassid, A. 1989. J Clin Invest. 83: 1774-7. PMID: 2540223
- Nitroglycerin-induced tolerance affects multiple sites in the organic nitrate bioconversion cascade. | Henry, PJ., et al. 1989. J Pharmacol Exp Ther. 248: 762-8. PMID: 2563771
- Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway. | Aguiar, AS., et al. 2016. Neurochem Res. 41: 64-72. PMID: 26323504
- Tolerance to relaxation in rat aorta: comparison of an S-nitrosothiol with nitroglycerin. | Kowaluk, EA., et al. 1987. Eur J Pharmacol. 144: 379-83. PMID: 3126076
- S-Nitroso-N-acetylpenicillamine impregnated endotracheal tubes for prevention of ventilator-associated pneumonia. | Homeyer, KH., et al. 2020. Biotechnol Bioeng. 117: 2237-2246. PMID: 32215917
- Covalently Bound S-Nitroso-N-Acetylpenicillamine to Electrospun Polyacrylonitrile Nanofibers for Multifunctional Tissue Engineering Applications. | Workman, CD., et al. 2021. ACS Biomater Sci Eng. 7: 5279-5287. PMID: 34695358
- Intrastriatal infusion of (+/-)-S-nitroso-N-acetylpenicillamine releases vesicular dopamine via an ionotropic glutamate receptor-mediated mechanism: an in vivo microdialysis study in chloral hydrate-anesthetized rats. | West, AR. and Galloway, MP. 1996. J Neurochem. 66: 1971-80. PMID: 8780025
- Intrabulbar infusions of (+/-)S-nitroso-N-acetylpenicillamine and L-arginine induce functional plasticity in the accessory olfactory bulb of female mice. | Okere, CO., et al. 1996. Neurosci Lett. 217: 197-9. PMID: 8916106
Inhibitor of:
Cofilin 1.Activator of:
β-tectorin, 1700042B14Rik, 1700047I17Rik2, 2210404J11Rik, 2410012M07Rik, 2410066E13Rik, 4921510H08Rik, 4921511H03Rik, 9130014G24Rik, ACTR10, AGP-8, Alsin, ARL9, ARMC2, ARMCX3, Arylsulfatase D, ASB-18, Astrotactin, Astrotactin 2, BEND6, BEND7, BI-1, BUP-1, C12orf50_1700017N19Rik, C12orf53_C530028O21Rik, C12orf55, C12orf62, C12orf63, C12orf74, C13orf31, C14orf176, C14orf25, C14orf73, C16orf92, C17orf72, C19orf22, C2orf18, C2orf44_BC068281, C2orf48, C2orf54, C2orf62, C2orf90, C5orf48, C6orf103, C8orf73, C9orf172, C9orf69, Calpain 15_Solh, CAPON, CBWD2, CCDC108, CCDC122, CCDC128, CCDC147, CCDC162, CCDC164, CCDC28A, CCDC42B, CCDC85A, CCDC92, CdkL4, CDY1, CLEC-2A, CLEC-2D, CLPSL1, CWF19L1, CYS1, DCDC2C, DCST2, DOC1, DSEL, DYX2_D130043K22Rik, ERMAP, FAHD2A, FAM113B, FAM123C, FAM130A1, FAM135A, FAM13b, FAM164B, FAM169B, FAM171B, FAM186B, FAM22D, FAM26E, FAM50B, FAM60A, FAM75A5, FAM90A1, FHDC1, GASP-2, GCS, GCS-α-2, Gm1027, Gm10332, Gm11062, Gm13247, Gm14139, Gm14306, Gm15070, golgin 45, GULP, HN1, HOP-1, I-Plastin, Importin-11, JAM4, Kap95, KIAA1033, KIAA1430_4933411K20Rik, KPI-2, KRIT1, LANCL3, LIR_6, LOC388963, LOC400986, LOC728379, LRRC57, LRRC73, Ly6G5c, LYG2, LYRM2, LYRM5, LYZL2, MAGE-B6, MGC26647, Mitoferrin 2, MNAB, MPPED1, MRP-S11, MRP-S18C, Msn2, Mucin 7, NCYM, NNP-1B_Rrp1b, OATP-I, OCIL, PCDHB9, PCNXL4, PCYOX1L, PMF-1, PNGase, POR1, PP2Cζ, PPP1R6, Protogenin, PTPN21, Rab 40A, Rit2, RNF182, SAMD3, Scand3, SLC39A13, SMGC, Smok3b, Smok3c, SNX30, Soggy-1, Spir-1, SREC-II, TCP-10c, Tdpoz1, Tdpoz4, TDRD12, TMCC3, TMEM114, TMEM117, TMEM132B, TMEM150A, TMEM169, TMEM177, TMEM179, Tmem247, TMTC2, Transcobalamin II, TTC30A, TTC31, TXNL1, UBL7, V1RE1, V1RE13, Vmn2r107, Vmn2r109, Vmn2r111, Vmn2r113, Vmn2r115, VSIG1, WDR20b, WDR21B, WDR63, XTP3-B, ZFP11, and ZNRF2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-S-Nitroso-N-acetylpenicillamine, 10 mg | sc-200319B | 10 mg | $73.00 | |||
(±)-S-Nitroso-N-acetylpenicillamine, 20 mg | sc-200319 | 20 mg | $112.00 | |||
(±)-S-Nitroso-N-acetylpenicillamine, 100 mg | sc-200319A | 100 mg | $367.00 |