Molecular structure of Puromycin Aminonucleoside, CAS Number: 58-60-6
Puromycin Aminonucleoside (CAS 58-60-6)
See product citations (7)
Alternate Names:
Puromycin Aminonucleoside is also known as PANS.
Application:
Puromycin Aminonucleoside is a glomerular epithelial cell toxin, and aminonucleoside portion of the antibiotic puromycin.
CAS Number:
58-60-6
Purity:
≥98%
Molecular Weight:
294.3
Molecular Formula:
C12H18N6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Puromycin Aminonucleoside is the aminonucleoside portion of the antibiotic puromycin. In rats, Puromycin Aminonucleoside is used in the study of focal and segmental glomerulosclerosis and the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with Puromycin Aminonucleoside-induced nephrotic syndrome has been studied. Puromycin Aminonucleoside is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.
Puromycin Aminonucleoside (CAS 58-60-6) References
- Protein gene product 9.5 is selectively localized in parietal epithelial cells of Bowman's capsule in the rat kidney. | Shirato, I., et al. 2000. J Am Soc Nephrol. 11: 2381-2386. PMID: 11095662
- Puromycin aminonucleoside induces glomerular epithelial cell apoptosis. | Sanwal, V., et al. 2001. Exp Mol Pathol. 70: 54-64. PMID: 11170791
- Synthesis of sulfated proteoglycans by bovine glomerular endothelial cells in culture. | Sörensson, J., et al. 2003. Am J Physiol Renal Physiol. 284: F373-80. PMID: 12388398
- Animal models of FSGS: lessons for pathogenesis and treatment. | Fogo, AB. 2003. Semin Nephrol. 23: 161-71. PMID: 12704576
- Effect of grape seed extract on puromycin-aminonucleoside-induced nephrosis in rats. | Mattoo, TK. and Kovacevic, L. 2003. Pediatr Nephrol. 18: 872-7. PMID: 12836089
- Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria. | Ni, Z. and Vaziri, ND. 2003. Biochim Biophys Acta. 1638: 129-37. PMID: 12853118
- Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? | McDonough, AA. and Biemesderfer, D. 2003. Curr Opin Nephrol Hypertens. 12: 533-41. PMID: 12920402
- Changes of atrial natriuretic Peptide system in rats with puromycin aminonucleoside-induced nephrotic syndrome. | Bae, EH., et al. 2009. Korean J Physiol Pharmacol. 13: 1-7. PMID: 19885019
- Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner. | Ha, TS., et al. 2016. Exp Cell Res. 340: 139-49. PMID: 26683996
- Role of autophagy in Puromycin Aminonucleoside-induced podocyte apoptosis. | Yu, S., et al. 2020. J Recept Signal Transduct Res. 40: 273-280. PMID: 32102592
- Puromycin aminonucleoside-induced podocyte injury is ameliorated by the Smad3 inhibitor SIS3. | Jiang, L., et al. 2020. FEBS Open Bio. 10: 1601-1611. PMID: 32583562
- Hirudin attenuates puromycin aminonucleoside-induced glomerular podocyte injury by inhibiting MAPK-mediated endoplasmic reticulum stress. | Long, C., et al. 2022. Drug Dev Res. 83: 1047-1056. PMID: 35277865
- Sinkihwan-gamibang ameliorates puromycin aminonucleoside-induced nephrotic syndrome. | Lee, HK., et al. 2022. Chin J Nat Med. 20: 177-184. PMID: 35369961
- The role of PTEN in puromycin aminonucleoside-induced podocyte injury. | Ren, Q., et al. 2022. Int J Med Sci. 19: 1451-1459. PMID: 36035365
- Reactive oxygen species and antioxidant defense in puromycin aminonucleoside glomerulopathy. | Gwinner, W., et al. 1997. J Am Soc Nephrol. 8: 1722-31. PMID: 9355075
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Puromycin Aminonucleoside, 10 mg | sc-200112 | 10 mg | $104.00 | |||
Puromycin Aminonucleoside, 50 mg | sc-200112A | 50 mg | $312.00 | |||
Puromycin Aminonucleoside, 100 mg | sc-200112B | 100 mg | $512.00 | |||
Puromycin Aminonucleoside, 500 mg | sc-200112C | 500 mg | $1607.00 | |||
Puromycin Aminonucleoside, 1 g | sc-200112D | 1 g | $3064.00 |