Cox-1 Background Information Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs (NSAIDs).
Cox-1 (11) Product Citations
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Cox-1 (11)
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Cox-1 (11) PE: sc-19998 PE. Intracellular FCM analysis of fixed and permeabilized U-937 cells. Black line histogram represents the isotype control, normal mouse IgG2b: sc-2868.
Cox-1 (11): sc-19998. Western blot analysis of Cox-1 expression in non-transfected 293T: sc-117752 (A), human Cox-1 transfected 293T: sc-114480 (B) and U-937 (C) whole cell lysates.
Cox-1 (11): sc-19998. Western blot analysis of Cox-1 expression in non-transfected 293T: sc-117752 (A), mouse Cox-1 transfected 293T: sc-126660 (B) and NIH/3T3 (C) whole cell lysates.
Cox-1 (11): sc-19998. Western blot analysis of Cox-1 expression in NIH/3T3 whole cell lysate.
Cox-1 (11): sc-19998. Western blot analysis of Cox-1 expression in U-937 (A) and CCD-1064Sk (B) whole cell lysates.
