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Integrin αX Antibody (B-Iy6): sc-19989

 |  Datasheet

(Based on data analysis)

  • Integrin αX Antibody (B-Iy6) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against a cell suspension of the heavily involved spleen of a human with hairy cell leukemia
  • recommended for detection of Integrin αX of human origin by IF and FCM
  • fluorescein (sc-19989 FITC) and phycoerythrin (sc-19989 PE) conjugates for FCM, 100 tests
 

See additional Integrin Antibodies including Integrin, Integrin alpha 1, Integrin alpha D, Integrin alpha E, Integrin alpha IIb, Integrin alpha IIIa, Integrin alpha IIIb, Integrin alpha L, Integrin alpha M, Integrin alpha V, Integrin alpha VIa, Integrin alpha VIb, Integrin alpha X, Integrin beta 1, Integrin beta Id, Integrin beta L1, Integrin alpha 2, Integrin beta 2, Integrin alpha 3, Integrin beta 3, Integrin alpha 4, Integrin beta 4, Integrin alpha 5, Integrin beta 5, Integrin alpha 6, Integrin beta 6, Integrin alpha 7, Integrin beta 7, Integrin alpha 8, Integrin beta 8, Integrin alpha 9, Integrin alpha 10 and Integrin alpha 11.

Also see Integrin Inhibitors for functional analysis of cellular responses to Integrin.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
IF   FCM   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Integrin αX Antibody (B-Iy6) sc-19989 200 µg/ml $279
Integrin αX Antibody (B-Iy6) FITC sc-19989 FITC 100 tests in 2 ml $292
Integrin αX Antibody (B-ly6) PE sc-19989 PE 100 tests in 2 ml $303
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Integrin αX siRNA (h) sc-35695 10 µM $258
Integrin αX (h)-PR sc-35695-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Integrin αX shRNA Plasmid (h) sc-35695-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Integrin αX shRNA (h) Lentiviral Particles sc-35695-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Integrin αX (h4): 293T Lysate sc-158645 100 µg/200 µl $205
HL-60 + PMA Cell Lysate sc-24705 500 µg/200 µl $104
THP-1 Cell Lysate sc-2238 500 µg/200 µl $104
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ITGAX 3687 16p11.2 NM_000887 P20702
151510
 


Integrin åX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with ∫2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin åX/∫2 shares similar properties of the åM/∫2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin åX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin åX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin åX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

Integrin αX Antibody (B-Iy6) Data
Click on image to enlarge
Integrin αX (B-ly6) PE: sc-19989 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG1: sc-2866.
Integrin αX (B-ly6): sc-19989. Immunofluorescence staining of methanol-fixed THP-1 cells showingmembrane staining.
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