epitope corresponding to phosphorylated Ser 87 of α-synuclein of human origin
recommended for detection of Ser 87 phosphorylated α-synuclein of human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
α-synuclein Background Information Synucleins are a novel class of GRK substrates. Synucleins (alpha, beta, gamma and synoretin) are highly expressed in brain, but are also found in numerous other tissues. The synuclein family members, including a-synuclein, are speculated to be involved in synaptic regulation and neuronal plasticity. a-synuclein, also designated NACP, PD1, PARK1 and SNCA, is localized to neuronal cell bodies and synapses and has been implicated in the pathogenesis of several neuro-degenerative disorders including Alzheimer’s and Parkinson’s diseases. a-synuclein is phosphorylated on serine residues Ser 129 and Ser 87. In addition, a-synuclein exists in a glycosylated form. The human a-synuclein gene maps to chromosome 4q21.
