FAS-L Background Information Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (also designated Apo-1) and its ligand (FAS-L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS. These findings strongly imply that targeted cell death is potentially mediated by the intercellular interactions of FAS with its ligand or effectors, and that FAS may be critically involved in CTL-mediated cytotoxicity.
FAS-L (NOK-1) Product Citations
See how others have used FAS-L (NOK-1): sc-19681 antibody and or FAS-L (NOK-1) antibody conjugates.
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FAS-L (NOK-1)
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FAS-L (NOK-1): sc-19681. Western blot analysis of FAS-L expression in K-562 (A) and HL-60 (B) whole cell lysates immunoprecipitated with FAS-L (NOK-1): sc-19681 and detected with FAS-L (C-178): sc-6237.
FAS-L (NOK-1): sc-19681. Western blot analysis of FAS-L expression in K-562 (A) and HL-60 (B) whole cell lysates immunoprecipitated with FAS-L (NOK-1): sc-19681 and detected with FAS-L (N-20): sc-834.
FAS-L (NOK-1): sc-19681. Indirect FCM analysis of L5178Y-human FAS-L stable transfectant cell line (B) and non-transfected L5178Y cells (A). Cells were treated with metalloproteinase inhibitor BB94 and stained with FAS-L (NOK-1) (orange), followed by PE-conjugated goat anti-mouse IgG. Clear line histograms represent the isotype control, normal mouse IgG1. Data kindly provided by Dr. Hideo Yagita at Juntendo University School of Medicine.
