CD2 Background Information CD2 (also designated E-rosette receptor) interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes, as well as on mouse B cells and rat splenic macrophages. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counterreceptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.
CD2 (RM2-5)
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CD2 (RM2-5): sc-19639. Western blot analysis of CD2 expression in BW5147 (A), CTLL-2 (B) whole cell lysates and mouse thymus tissue extract (C).
CD2 (RM2-5) PE: sc-19639 PE. FCM analysis of mouse peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal rat IgG2b: sc-2873.
