IL-2Rβ (TM-β1) Antibody: sc-19583

IL-2Rβ Background Information
The IL-2 receptor is a multicomponent complex consisting of three subunits, å, ∫ and ©, each of which is required for high affinity binding of IL-2. The a chain functions primarily in binding IL-2, whereas the ∫ and © chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain high affinity ligand binding cytokine receptors. However, it is now well established that the IL-2R © chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Rå and IL-7Rå respectively, while the common subunit is referred to as ©c. Although the common © chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the gc chain is also a subunit of IL-13R.