epitope mapping within an internal region of MPc2 of human origin
recommended for detection of MPc2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including bovine and porcine
MPc2 Background Information Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing (1,2) and Hox gene regulation (3) by altering chromatin structure during transcription (1). The PcG protein MPc2, also known as CBX4, PC2 or HPc2, maps to human chromosome 17q25.3 (4). MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1 (1,2,5). MPc2 is a repressor of proto-oncogene activity, thus interference with MPc2 function can lead to depression of proto-oncogene transcription and subsequently to cellular transformation (6). MPc2 is able to act as a long range transcriptional silencer (1,7). MPc2 is expressed in the human osteosarcoma cell line U-20S (6). MPc2 is part of a large multiprotein complex that also contains other PcG proteins including Bmi-1 (1,7).
MPc2 (T-20) Product Citations
See how others have used MPc2 (T-20): sc-19299 antibody and or MPc2 (T-20) antibody conjugates.
