epitope mapping near the N-terminus of M33 of human origin
recommended for detection of M33 of human and, to a lesser extent, mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including canine
M33 Background Information Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing and Hox gene regulation by altering chromatin structure during transcription. The PcG protein M33, also known as CBX2 or MOD2, controls the accessibility of retinoic acid response elements in the vicinity of Hox genes regulatory regions by direct and/or indirect mechanisms. MPc2 and MPc3 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1. Both M33 and BMI-1 have an influence on positions effect variegation (PEV), which is the suppression of protein expression in a proportion of cells. M33 deficiency may cause sex reversal by interfering with steps upstream of the Y-chromosome-specific SRY gene. M33 may also be involved in two different pathologies: the campomelic syndrome, an inherited disorder, and neoplastic disorders linked to allele loss in this region.
M33 (N-20) Product Citations
See how others have used M33 (N-20): sc-19295 antibody and or M33 (N-20) antibody conjugates.
