TRAF4 (N-16) Antibody: sc-1921

TRAF4 Background Information
The tumor necrosis factor family (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine-rich extracellular domains. Members of this family include TNF-RI, TNF-RII and CD40 (1-3). Ligands for these receptors can be small, secreted proteins such as TNF or type II integral membrane proteins as is the case for the CD40 ligand, CD40L (3,4). While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, activation of TNF-R or CD40 has been shown to induce the nuclear translocation of NFkB (5,6). Members of the TRAF (TNF receptor-associated factor) family have been implicated in this process (5,6). Four members have thus far been described and are designated TRAF1, TRAF2, TRAF3 (variously referred to as CRAF1, LAP1 or CD40bp) and TRAF4 (7). TRAF4, originally termed CART1, is specifically expressed in breast carcinomas, and is localized to the nucleus in such tissues (8).