 |
- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of WT1 of human origin
- recommended for detection of WT1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-192 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-192 X, 200 µg/0.1 ml
- agarose conjugate for IP studies, sc-192 AC, 500 µg/0.25 ml agarose
|
|
| |
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WT1 Background Information
Wilms’ tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and, like retinoblastoma, is observed in both sporadic and inherited forms. The Wilms’ tumor locus has been mapped at chromosome 11p13 as a tumor suppressor gene which encodes a DNA binding protein with four zinc fingers and a glutamine-proline rich amino-terminus. The Wilms’ tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators. However, in contrast to Egr transcription factors, WT1 behaves as a transcriptional repressor in transient transfection assays with synthetic promotor constructs.
| WT1 (C-19) Product Citations |
See how others have used WT1 (C-19): sc-192 antibody and or WT1 (C-19) antibody conjugates.
143 total citations Loading citations.
|
| |
|
|
|
WT1 (C-19)
Click on image to enlarge
|
|
WT1 (C-19): sc-192. Western blot analysis of WT1 expression in MCF7 whole cell lysate (A) and nuclear extract (B).
WT1 (C-19): sc-192. Immunoperoxidase staining of formalin-fixed, paraffin-embedded pediatric renal tumor showing nuclear localization of WT1. Kindly provided by Pamila Ramani.
WT1 (C-19): sc-192. Immunofluorescence staining of normal mouse kidney frozen section showing nuclear staining.
|
|
Download
|
|
