XAF1 (C-16) Antibody: sc-19194

XAF1 Background Information
X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1) is a zinc finger protein that blocks the anti-apoptotic activity of XIAP. XIAP is a member of the family of intrinsic inhibitors of apoptosis proteins (IAPs), which suppress apoptosis through the inhibition of caspases. In the presence of XAF1, XIAP protein redistributes from the cytosol to the nucleus. XAF1 transcripts (3.9-, 4.5-, 6.0- and 7.0-kb) are present at high levels in heart and ovary. Low expression of XAF1 mRNA is an indicator for certain cancers (WM164 melanoma, WM35 melanoma, U937 pro-monocytic leukemia and HT1080 fibrosarcoma), suggesting that low levels of XAF1 transcript may enhance cancer cell-survival through the relative increase in XIAP anti-apoptotic function. IFN-å and IFN-∫ activate the human XAF1 gene, which maps to chromosome 17p13.1.