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PUMAα Antibody (N-19): sc-19187

 |  Datasheet

(Based on data analysis)

  • PUMAα Antibody (N-19) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the N-terminus of PUMAα of human origin
  • recommended for detection of PUMAα of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
  • blocking peptide, sc-19187 P
  • See 14 citations for PUMAα Antibody (N-19)
 

See additional PUMA Antibodies including PUMA, PUMA alpha, PUMA beta and PUMA delta.

Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PUMAα Antibody (N-19) sc-19187 200 µg/ml $279
PUMAα (N-19) P sc-19187 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PUMA siRNA (h) sc-37153 10 µM $258
PUMA siRNA (m) sc-37154 10 µM $258
PUMAα (h)-PR sc-37153-PR 10 µM, 20 µl $23
PUMAα (m)-PR sc-37154-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PUMAα shRNA Plasmid (h) sc-37153-SH 20 µg $520
PUMAα shRNA Plasmid (m) sc-37154-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PUMAα shRNA (h) Lentiviral Particles sc-37153-V 200 µl $625
PUMAα shRNA (m) Lentiviral Particles sc-37154-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
K-562 nuclear extract sc-2130 250 µg/0.05 ml $143
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
MOLT-4 Cell Lysate sc-2233 500 µg/200 µl $104
U-937 Cell Lysate sc-2239 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human BBC3 27113 19q13.32 NM_014417 Q9BXH1
 605854
Mouse Bbc3 170770 7 A2 Q99ML1
 N/A
 

PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAå, ∫, © and ∂. Both PUMAå and PUMA∫ contain a BH3 domain, while PUMA© and PUMA∂ lack this domain. The BH3 domain is essential for binding of PUMAå and PUMA∫ to Bcl-2 or Bcl-xL. PUMA is an initiator of ©-radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region.

PUMAα Antibody (N-19) Product Citations
See how others have used PUMAα Antibody (N-19) and or PUMAα Antibody (N-19) conjugates.


14 total citations
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PUMAα Antibody (N-19) Data
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sc-19187
PUMAα (N-19): sc-19187. Western blot analysis of PUMAα expression in K-562 (A), Jurkat (B), MOLT-4 (C) and U-937 (D) whole cell lysates.
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