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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of TIF1β of human origin
- recommended for detection of TIF1β of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- blocking peptide, sc-19169 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-19169 X, 200 µg/0.1 ml
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Ordering Information
Recommended Support Products:
(click button of application of choice)
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
TRIM28 |
10155 |
19q13.43 |
NM_005762 |
Q13263
|
601742 |
| Mouse |
Trim28 |
21849 |
7 A1 |
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Q62318
|
N/A |
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TIF1β Background Information
TIF1∫, for transcriptional intermediary factor 1-beta, also designated KAP1(for KRAB-associated protein 1), TF1∫ and TRIM28 (for tripartif motif-containing 28), is a member of the tripartif motif family characterized by three zinc-binding domains, a RING finger, B-boxes and a coiled-coil domain (1,2,4). Like TIF1å, TIF1∫ contains both a Cys/His PHD (plant homeodomain) finger and bromodomain that form a cooperative unit required for transcriptional repression (3,5). TIF1∫ mediates transcriptional control by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors and by binding DNA through its zinc finger (3,6). The human TIF1∫ gene maps to human chromosome 19q13.4 and encodes an 835 amino acid nuclear protein (3,4). |
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TIF1β (Y-16)
Click on image to enlarge
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TIF1β (Y-16): sc-19169. Western blot analysis of TIF1β expression in non-transfected 293T: sc-117752 (A), human TIF1β transfected 293T: sc-116358 (B) and CCRF-CEM (C) whole cell lysates. TIF1β (Y-16): sc-19169. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
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