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- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-1909-R
- epitope mapping at the C-terminus of Smad4 of human origin
- recommended for detection of Smad4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-1909 P
- agarose conjugate for IP studies, sc-1909 AC, 500 µg/0.25 ml agarose
- TransCruz reagent for Gel Supershift and ChIP applications, sc-1909 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
SMAD4 |
4089 |
18q21.2 |
NM_005359 |
Q13485
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n/a |
| Mouse |
Smad4 |
17128 |
18 E2 |
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P97471
|
N/A |
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Smad4 Background Information
Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFß/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFß and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFß signaling by interfering with TGFß-mediated phosphorylation of other Smad family members.
| Smad4 (C-20) Product Citations |
See how others have used Smad4 (C-20): sc-1909 antibody and or Smad4 (C-20) antibody conjugates.
18 total citations Loading citations.
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Smad4 (C-20)
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Smad4 (C-20): sc-1909. Western blot analysis of Smad4 expression in Ramos whole cell lysate.
Smad4 (C-20): sc-1909. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.
Smad4 (C-20)-R: sc-1909-R. Western blot analysis of Smad4 expression in non-transfected: sc-117752 (A) and mouse Smad4 transfected: sc-123641 (B) 293T whole cell lysates. Smad4 (C-20)-R: sc-1909-R. Western blot analysis of Smad4 expression in Ramos whole cell lysate.
Smad4 (C-20): sc-1909. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells.
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