epitope mapping at the C-terminus of HMG-17 of human origin
recommended for detection of HMG-17, LOC646049, LOC729505 and LOC646853 of mouse, rat and human origin by WB, IF and ELISA; may cross-react with hCG_1793639 and LOC644992; also reactive with additional species, including equine, canine, bovine, porcine and avian
blocking peptide, sc-19073 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-19073 X, 200 µg/0.1 ml
HMG-17 Background Information The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription (1–5). HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates (1–3,5). HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence (1–3). Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber (1–3). In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development (2).
