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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of ADAR2 of human origin
- recommended for detection of ADAR2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-19068 P
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Ordering Information
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ADAR2 Background Information
ADAR2, also designated adenosine deaminase, RNA-specific (RED1), RNA-editing enzyme 1, DRABA2, DRADA2, ADAR2a-L1, ADAR2a-L2 and ADAR2a-L3, mediates RNA editing by destabilizing RNA through deamination of adenosine to inosine. ADAR2 is responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. It can modify its own pre-mRNA and generate new splice sites. Translocation of endogenous ADAR2 from the nucleolus to the nucleoplasm results in increased editing of endogenous ADAR2 substrates. Alternative splicing of this gene results in several transcript variants that may influence RNA editing. RNA editing involves the deamination of adenosines at specific sites, the result of which can be a change in the amino acid sequence of the protein so that it differs from that predicted by the sequence of the DNA. |
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ADAR2 (K-20)
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ADAR2 (K-20): sc-19068. Western blot analysis of ADAR2 expression in non-transfected: sc-117752 (A) and human ADAR2 transfected: sc-117039 (B) 293T whole cell lysates. |
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