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mtTFA Antibody (K-18): sc-19050

 |  Datasheet

(Based on data analysis)

  • mtTFA Antibody (K-18) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of mtTFA of human origin
  • recommended for detection of mtTFA of human and, to a lesser extent, mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
  • blocking peptide, sc-19050 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-19050 X, 200 µg/0.1 ml
  • See 6 citations for mtTFA Antibody (K-18)
 

See additional mtTFA Antibodies.

Also see mtTFA Activators for functional analysis of cellular responses to mtTFA.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   Gel Shift   ChIP   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
mtTFA Antibody (K-18) sc-19050 200 µg/ml $279
mtTFA (K-18) P sc-19050 P
(peptide)
 100 µg/0.5 ml $61
mtTFA Antibody (K-18) X sc-19050 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
mtTFA siRNA (h) sc-38053 10 µM $258
mtTFA siRNA (m) sc-45912 10 µM $258
mtTFA siRNA (r) sc-156067 10 µM $258
mtTFA (h)-PR sc-38053-PR 10 µM, 20 µl $23
mtTFA (m)-PR sc-45912-PR 10 µM, 20 µl $23
mtTFA (r)-PR sc-156067-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
mtTFA shRNA Plasmid (h) sc-38053-SH 20 µg $520
mtTFA shRNA Plasmid (m) sc-45912-SH 20 µg $520
mtTFA shRNA Plasmid (r) sc-156067-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
mtTFA shRNA (h) Lentiviral Particles sc-38053-V 200 µl $625
mtTFA shRNA (m) Lentiviral Particles sc-45912-V 200 µl $625
mtTFA shRNA (r) Lentiviral Particles sc-156067-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
CCRF-CEM Cell Lysate sc-2225 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TFAM 7019 10q21.1 NM_003201 Q00059
 600438
 

mtTFA (mitochondrial transcription factor A), also known as mtTF1, TFAM, TCF6 (for transcription factor 6-like1), TCF6L2 and tsHMG, is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse, testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy, exercise intolerance and muscle wasting.

mtTFA Antibody (K-18) Product Citations
See how others have used mtTFA Antibody (K-18) and or mtTFA Antibody (K-18) conjugates.


6 total citations
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mtTFA Antibody (K-18) Data
Click on image to enlarge
sc-19050
mtTFA (K-18): sc-19050. Western blot analysis of mtTFA expression in A-431 (A) and CCRF-CEM (B) whole cell lysates.
sc-19050
mtTFA (K-18): sc-19050. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing cytoplasmic staining of glandular cells.
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