group V PLA2 Background Information Phospholipase A2s (PLA2s) constitute a family of esterases that hydrolyze the sn-2-acyl ester bond in glycerophospholipid molecules. These enzymes are generally calcium-dependent and have been found both intra- and extracellularly. By hydrolyzing the sn-2 bond in glycerophospholipids, PLA2s release fatty acids. One such fatty acid, arachidonic acid, generates the substrates for the initiation of the arachidonic acid cascade that produces various eicosanoids (i.e., prostaglandins, leukotrienes and thromboxanes), many of which are potent mediators of inflammation. PLA2s include both the relatively low molecular weight group I, group II and group V enzymes and the form known as cytoplasmic PLA2 (cPLA2). cPLA2 is present in macrophages, and hydrolyzes the sn-2 fatty acyl ester bond of phospholipids to produce a free fatty acid and a lysophospholid.
group V PLA2 (3G1)
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group V PLA2 (3G1): sc-18828. Western blot analysis of human recombinant group V PLA2.
group V PLA2 (3G1) PE: sc-18828 PE. Intracellular FCM analysis of fixed and permeabilized A10 cells. Black line histogram represents the isotype control, normal mouse IgG1: sc-2866.
