epitope mapping within an internal region of LKLF of human origin
recommended for detection of LKLF, GKLF and EKLF of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine, porcine and avian
LKLF Background Information The Kruppel-type zinc finger transcription factors comprise a conserved family of DNA binding proteins that are important in developmental regulation (1–4). The Kruppel zinc finger transcription factor was initially identified in Drosophila as a segmentation gene (5). Kruppel-like factors that have been characterized in mammals include erythroid Krupple-like transcription factor (EKLF), lung Krupple-like transcription factor (LKLF) and gut Krupple-like transcription factor (GKLF) (6–8). EKLF is expressed principally in erythroid tissues (6), and LKLF expression is limited to the lung (7). GKLF is found predominantly in gut and has been shown to be expressed during growth arrest (8). In a developing mouse embryo, LKLF is necessary for normal tunica media formation and blood vessel stabilization (9). LKLF is also sufficient to program quiescence in T cells by negatively regulating the c-Myc-dependent pathway (10). The gene for human LKLF maps to chromosome 19p13.11-p13.13 (11).
LKLF (C-13)
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LKLF (C-13): sc-18692. Western blot analysis of GKLF expression in non-transfected: sc-117752 (A) and human GKLF transfected: sc-114641 (B) 293T whole cell lysates.
LKLF (C-13): sc-18692. Western blot analysis of GKLF expression in non-transfected: sc-117752 (A) and mouse GKLF transfected: sc-125385 (B) 293T whole cell lysates.
