karyopherin β1 (C-19) Antibody: sc-1863

karyopherin β1 Background Information
Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin a1 and karyopherin b1 subunits. Karyopherin a1 functions in the recognition and targeting of substrates destined for nuclear import, while karyopherin b1 serves as an adapter, tethering the karyopherin a1/substrate complex to docking proteins on the nuclear envelope, termed nucleoporins. Karyopherin a2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA-1). Certain RNA-binding proteins are imported to the nucleus by karyopherin b2, and karyopherin b3 appears to be involved in the import of some ribosomal proteins.