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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Bcl-3 of human origin
- recommended for detection of Bcl-3 of mouse, rat and human origin by WB, IP, IF, ihc(P) and ELISA
- blocking peptide, sc-185 P
- TransCruz reagent for ChIP application, sc-185 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
BCL3 |
602 |
19q13.31 |
NM_005178 |
P20749
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109560 |
| Mouse |
Bcl3 |
12051 |
7 A3 |
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Q9Z2F6
|
N/A |
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Bcl-3 Background Information
On the basis of both functional and structural considerations, members of the IkB family of proteins can be divided into three groups. The first of these groups, IkB-a, includes the avian protein pp40 and the mammalian Mad 3, both of which inhibit binding of p50-p65 NFkB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to kB sites, suggesting that the IkB-a family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IkB family is represented by a protein designated IkB-b. The third group of IkB proteins is represented by IkB-g, a protein identical in sequence with the C-terminal domain of the p110 precursor of NFkB p50 and expressed predominantly in lymphoid cells. The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that functions as an IkB-like molecule for native NFkB but is specific for the p50 subunit.
| Bcl-3 (C-14) Product Citations |
See how others have used Bcl-3 (C-14): sc-185 antibody and or Bcl-3 (C-14) antibody conjugates.
44 total citations Loading citations.
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Bcl-3 (C-14)
Click on image to enlarge
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Bcl-3 (C-14): sc-185. Western blot analysis of Bcl-3 expression in NAMALWA (A) and WEHI-3 (B) whole cell lysates.
ChIP analysis of cofactor occupancy dynamics on the KAI1 promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, HDAC3 (H-99): sc-11417, HDAC3 (N-19): sc-8138, Bcl-3 (C-14): sc-185, Bcl-3 (H-146): sc-13038. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek et al., Cell 2002, 110: 55-67. Bcl-3 (C-14): sc-185. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic and nuclear staining of glandular cells.
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