epitope mapping within an internal region of SIP1 of human origin
recommended for detection of SIP1 (Smad interacting protein 1) of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and porcine
SIP1 Background Information SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.
SIP1 (L-20) Product Citations
See how others have used SIP1 (L-20): sc-18392 antibody and or SIP1 (L-20) antibody conjugates.
