Fra-1 Background Information The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c-Fos gene family, including c-Fos, Fos B, Fra-1 and Fra-2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers that bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
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Fra-1 (N-17)
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Fra-1 (N-17): sc-183. Western blot analysis of Fra-1 expression in NIH/3T3 nuclear extract.
Fra-1 (N-17): sc-183. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic and nuclear staining.
Fra-1 (N-17): sc-183. Immunofluorescence staining of normal mouse intestine frozen section showing nuclear staining.
Fra-1 (N-17): sc-183. Western blot analysis of Fra-1 expression in 3611-RF (A) and PMA-induced 3611-RF (B) nuclear extracts.
Fra-1 (N-17): sc-183. Western blot analysis of Fra-1 expression in non-transfected: sc-117752 (A) and human Fra-1 transfected: sc-176608 (B) 293T whole cell lysates.
