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home » Membrane Receptors » c-Kit Antibody / c-Kit Antibodies » p-c-Kit (Tyr 568/570): sc-18076

p-c-Kit (Tyr 568/570) Antibody: sc-18076

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-18076-R
  • epitope corresponding to dually phosphorylated Tyr 568 and Tyr 570 of c-Kit of mouse origin
  • recommended for detection of Tyr 568 and Tyr 570 dually phosphorylated c-Kit of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-18076 P
 
Additional c-Kit Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human KIT 3815 4q12 NM_000222 P10721
 606764
Mouse Kit 16590 5 C3.3 P05532
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-c-Kit (Tyr 568/570) sc-18076 200 µg/ml $279
p-c-Kit (Tyr 568/570) sc-18076 P
(peptide)
 100 µg/0.5 ml $61
p-c-Kit (Tyr 568/570) sc-18076-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100,000 units $462
Lambda Phosphatase sc-200312A 20,000 units $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Kit siRNA (h) sc-29225 10 µM $258
c-Kit siRNA (m) sc-29852 10 µM $258
c-Kit (h)-PR sc-29225-PR 10 µM $23
c-Kit (m)-PR sc-29852-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Kit shRNA Plasmid (h) sc-29225-SH 20 µg $520
c-Kit shRNA Plasmid (m) sc-29852-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
c-Kit shRNA (h) Lentiviral Particles sc-29225-V 200 µl $625
c-Kit shRNA (m) Lentiviral Particles sc-29852-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
A-431 + EGF Whole Cell Lysate sc-2202 500 µg/200 µl $104

c-Kit Background Information
The c-Kit proto-oncogene has been identified as a member of the receptor tyrosine kinase family and more specifically has been shown to be closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene, v-Kit, encodes a transmembrane receptor. c-Kit has also been show to be identical with the product of the W locus in mice and as such is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and shown to be encoded at the murine steel (SI) locus. Two sites on c-Kit are able to bind SH2(CHK), the Tyr 568/570 diphosphorylated sequence and the monophosphorylated Tyr 721 sequence. However, only Tyr 568/570 has been suggested to bind directly to SH2(CHK). The Tyr 568 and Tyr 570 residues are phosphorylated in vivo following ligand-stimulation.

p-c-Kit (Tyr 568/570) Product Citations
See how others have used p-c-Kit (Tyr 568/570): sc-18076 antibody and or p-c-Kit (Tyr 568/570) antibody conjugates.


3 total citations
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p-c-Kit (Tyr 568/570)
Click on image to enlarge
sc-18076
p-c-Kit (Tyr 568/570)-R: sc-18076-R. Western blot analysis of c-Kit phosphorylation in untreated (A), EGF treated (B) and EGF and lambda protein phosphatase treated (C) A-431 whole cell lysates.
sc-18076
p-c-Kit (Tyr 568/570)-R: sc-18076-R. Western blot analysis of c-Kit phosphorylation in untreated (A) and EGF treated (B) A-431 whole cell lysates.
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