β-1,4-Gal-T4 (M-15) Antibody: sc-18002

β-1,4-Gal-T4 Background Information
Enzymatic glycosylation of proteins and lipids is an important biological process. A large number of glycosyltransferases synthesize a wide variety of glycoconjugates (1,2). A novel putative member of the human UDP-galactose:beta-N-acetylgucosamine ∫-1,4-galactosyltransferase family, designated ∫-1,4-Gal-T4, encodes a type II membrane protein which has significant sequence similarity to other ∫-1,4-galactosyltransferases. ∫-1,4-Gal-T4 catalyzes glycosylation of glycolipids with terminal ∫-GlcNAc. Unlike ∫-1,4-Gal-T1, -T2 and -T3, ∫-1,4-Gal-T4 does not transfer galactose to asialo-agalacto-fetuin, asialo-agacto-transferrin or ovalbumin. ∫-1,4-Gal-T4 has a very restricted pattern of tissue expression (3,4). ∫-1,4-Gal-T4 is localized to two subcellular compartments, the Golgi complex, where it participates in cellular glycosylation, and the plasma membrane, where it functions as a receptor for oligosaccharide ligands on opposing cells or in the extracellular matrix (5).