epitope mapping at the C-terminus of TBX15 of mouse origin
recommended for detection of TBX15 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and porcine
blocking peptide, sc-17893 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-17893 X, 200 µg/0.1 ml
TBX15 Background Information The T-box (Tbx) motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation (1). The Tbx gene family are largely conserved throughout metazoan evolution, and these genes code for putative transcription factors that share a uniquely defining DNA-binding domain (2). Tbx genes are a family of developmental regulators with more than 20 members recently identified in invertebrates and vertebrates (3,4). Mutations in Tbx genes are associated with the onset of several human diseases (4). Our understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/Brachyury, which is a transcription activator (4). The Tbx genes constitute a family of transcriptional regulatory genes that are implicated in a variety of developmental processes ranging from the formation of germ layers to the organizational patterning of the central nervous system (5,6). TBX15, (T-box transcription factor TBX15), also designated TBX14, is a 602 amino acid protein. Mutations in the TBX15 gene are associated with Cousin syndrome a disorder characterized by short stature, craniofacial dysmorphism and hypoplasia of scapula and pelvis.
