MKP-2 (F-10) Antibody: sc-17821

MKP-2 Background Information
MKP-2 (MAP kinase phosphatase 2, Dual specificity protein phosphatase 4 (DUSP4)) is a phoshpatase involved in the complex MAPKKK cascade. MKP-2 belongs to the protein-tyrosine phosphatase family (Non-receptor class dual specificity subfamily) and contains one rhodanese domain and one tyrosine-protein phosphatase domain. A dual specificity protein phosphatase, MKP-2 has a stringent substrate specificity for MAPKs. It acts to regulate mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK 1 and ERK 2. Transcription factor E2F-1, which is responsible for mediating apoptosis and suppressing tumorigenesis, acts as a transcriptional regulator of MKP-2. E2F-1 is physically associated with the MKP-2 promoter and can transactivate the promoter of the MKP-2 gene. Specifically, E2F-1 binds to a perfect palindromic motif in the MKP-2 promoter. MKP-2 is an essential cell death mediator in the E2F-1 pathway and may lead to the development of new strategies for cancer treatment.