Histone Deacetylase 3 (HDAC3) Antibody (B-12): sc-17795

HDAC3 Antibody (B-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Histone Deacetylase 3 (HDAC3) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HDAC3 antibody (B-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HDAC3 plays a crucial role in the regulation of gene expression by removing acetyl groups from histones, which leads to chromatin condensation and transcriptional repression. This deacetylation process is vital for maintaining cellular homeostasis and regulating various biological processes, including cell cycle progression, differentiation, and apoptosis. Dysregulation of HDAC3 has been implicated in several diseases, including cancer, where aberrant histone deacetylation can lead to the silencing of tumor suppressor genes. Understanding HDAC3 function and interactions with other proteins, such as histone acetyltransferases GCN5 and p300, is essential for elucidating complex regulatory networks governing gene expression and developing targeted therapies in diseases associated with epigenetic modifications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Histone Deacetylase 3 (HDAC3) Antibody (B-12) has 28 citations in a variety of scientific publications.

Primary antibodies like Anti-Histone Deacetylase 3 (HDAC3) Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Histone Deacetylase 3 (HDAC3) Antibody (B-12) Specifications

Alternate Product Name: HDAC3

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 330-428

Epitope Target: HDAC3

Epitope Species: human

Product Reactivity/Detection: HDAC3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 28 citations in various scientific publications

Available Conjugates/Forms for Histone Deacetylase 3 (HDAC3) Antibody (B-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Histone Deacetylase 3 (HDAC3) antibody is Histone Deacetylase 3 (HDAC3) Antibody (A-3): sc-376957.