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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Cdk5 of human origin
- recommended for detection of Cdk5 of mouse, rat and human origin by WB, IP, KA, IF, IHC(P) and ELISA
- blocking peptide, sc-173 P
- agarose conjugate for IP studies, sc-173 AC, 500 µg/0.25 ml agarose
- HRP conjugate, sc-173 HRP, 200 µg/ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CDK5 |
1020 |
7q36.1 |
NM_004935 |
Q00535
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123831 |
| Mouse |
Cdk5 |
12568 |
5 A3 |
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P49615
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N/A |
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Cdk5 Background Information
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Cdk5 is thought to be involved in the G1-S transition of the cell cycle and is highly expressed in mature neurons. Activity of Cdk5 increases significantly during neuronal differentiation. Cdk5 has been postulated to be a neurofilament or tau protein kinase, based on its ability to phosphorylate these proteins in vitro.
| Cdk5 (C-8) Product Citations |
See how others have used Cdk5 (C-8): sc-173 antibody and or Cdk5 (C-8) antibody conjugates.
126 total citations Loading citations.
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Cdk5 (C-8)
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Cdk5 (C-8): sc-173. Western blot analysis of Cdk5 expression in HeLa (A), K-562 (B), Jurkat (C) and SK-BR-3 (D) phorbol ester-induced nuclear extracts.
Western blot analysis of -catenin phosphorylation in untreated (A,D), calyculin A treated (B,E) and calyculin A and lambda protein phosphatase treated (C,F) SH-SY5Y whole cell lysates. Antibodies tested include p-Cdk5 (Tyr 15)-R: sc-12918-R (A,B,C) and Cdk5 (C-8): sc-173 (D,E,F). Cdk5 (C-8): sc-173. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear staining of cells in seminiferous ducts.
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