epitope mapping within an internal region of TAF II p250 of human origin
recommended for detection of TAF II p250 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
blocking peptide, sc-17134 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-17134 X, 200 µg/0.1 ml
TAF II p250 Background Information TFIID is a general transcription factor which initiates pre-initiation complex assembly through direct interaction with the TATA promoter element. It is a multi-subunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs). Although native TFIID can mediate both activator-independent (basal) and activator-dependent transcription in reconstituted systems, TBP can mediate only basal transcription. The largest subunit (TAF) of TFIID is a protein designated TAF II p250. Of interest, TAF II p250 has been cloned and shown to be identical to CCG1, a nuclear DNA-binding protein known to be important for cell cycle progression. This part of TAF II p250 may serve a specific function in activation of a subset of genes important for cell cycle progression.
TAF II p250 (L-20) Product Citations
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TAF II p250 (L-20)
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TAF II p250 (L-20): sc-17134. Western blot analysis of TAF II p250 expression in K-562 nuclear extract.
