p-AchRβ1 (Tyr 390) Antibody: sc-17087

AchRβ1 Background Information
Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChR∫1, also known as CHRNB, CMS1D, CMS2A, SCCMS or CHRNB1, is a 501 amino acid protein that belongs to the ligand-gated ionic channel family. Defects in the gene encoding AChR∫1 may be the cause of congenital myasthenic syndrome slow-channel type (SCCMS), which is characterized by muscle weakness affecting the axial and limb muscles, the ocular muscles and the facial and bulbar musculature.