 |
- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of CAS of human origin
- recommended for detection of CAS of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-1708 P
|
|
| |
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CSE1L |
1434 |
20q13.13 |
NM_001316 |
P55060
|
601342 |
| Mouse |
Cse1l |
110750 |
2 H3 |
|
Q9ERK4
|
N/A |
| |
CAS Background Information
Cellular apoptosis susceptibility protein (CAS), also called Exportin 2, is a 971 amino acid member of the CSE1 family. CAS mediates Importin å re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm. In the nucleus, CAS binds cooperatively to Importin å and to the GTPase Ran in its GTP-bound (active) form. This complex binds to nucleoporins as it docks to the nuclear pore complex. Once in the cytoplasm, the complex dissociates and Importin å is released and CAS returns to the nuclear compartment and the process begins anew. CAS can be detected highly in proliferating cells. Three isoforms of CAS have been named due to alternative splicing. Isoform 1 is the full length, 971 amino acid protein. Isoform 2 contains an alternative sequence for amino acids 190-195 and is missing amino acids 196-971. Isoform 3 contains an alternative sequence for amino acids 943-945 and is missing amino acids 946-971.
| CAS (C-20) Product Citations |
See how others have used CAS (C-20): sc-1708 antibody and or CAS (C-20) antibody conjugates.
5 total citations Loading citations.
|
| |
|
|
|
CAS (C-20)
Click on image to enlarge
|
|
CAS (C-20): sc-1708. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tumor showing staining associated with select nuclei (A). Immunofluorescence staining of methanol-fixed HeLa cells showing cytoskeletal localization (B).
Western blot analysis of CAS in SW480 (A,B), A549 (C), MOLT-4 (D) and HeLa (E) nuclear extracts. Antibodies tested include CAS (C-20): sc-1708 (A) and CAS (N-19): sc-1709 (B-E). CAS siRNA (h): sc-29908. Western blot analysis of CAS expression in non-transfected control (A) and CAS siRNA transfected (B) HeLa cells. Blot probed with CAS (C-20): sc-1708. α-actinin (H-2): sc-17829 used as specificity and loading control. |
|
Download
|
|
