epitope mapping within an internal region of MTHFR of human origin
recommended for detection of MTHFR of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
MTHFR Background Information 5,10-methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the folate-dependent regulation of methionine and homocysteine concentrations. MTHFR catalyzes the reduction of 5,10-methylenetetrahydrofolate (methyleneTHF) to 5- methyltetrahydrofolate (methylTHF). MethylTHF, the predominate form of circulating folate, is the principle carbon donor for homocysteine methylation, a reaction that yields methionine. Folate prevents neural tube defects, and can lower homocysteine levels, suggesting that MTHFR function is important in preventing cardiovascular disease. Mutations at the MTHFR gene may influence vascular changes, predisposition to leukemia, coronary artery disease and hyperhomocysteinemia.
MTHFR (N-20) Product Citations
See how others have used MTHFR (N-20): sc-17079 antibody and or MTHFR (N-20) antibody conjugates.
