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p-CaM I Antibody (Ser 81): sc-17019

 |  Datasheet

(Based on data analysis)
  • p-CaM I Antibody (Ser 81) is a goat polyclonal IgG provided at 200 µg/ml; also available as rabbit IgG provided at 200 µg/ml, sc-17019-R
  • recommended for detection of Ser 81 phosphorylated CaM I of mouse, rat and human origin by WB and IF; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-17019 P
 

See additional CaM Antibodies.

Also see CaM Inhibitors for functional analysis of cellular responses to CaM.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-CaM I Antibody (Ser 81) sc-17019 200 µg/ml $279
p-CaM I (Ser 81) P sc-17019 P
(peptide)
 100 µg/0.5 ml $61
p-CaM I Antibody (Ser 81)-R sc-17019-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CaM I siRNA (h) sc-29896 10 µM $258
CaM I siRNA (m) sc-29897 10 µM $258
CaM I (h)-PR sc-29896-PR 10 µM, 20 µl $23
CaM I (m)-PR sc-29897-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CaM I shRNA Plasmid (h) sc-29896-SH 20 µg $520
CaM I shRNA Plasmid (m) sc-29897-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
CaM I shRNA (h) Lentiviral Particles sc-29896-V 200 µl $625
CaM I shRNA (m) Lentiviral Particles sc-29897-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CALM1 801 14q32.11 NM_006888 P62158
 114180
Mouse Calm1 12313 12 E P62204
 N/A
 

The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in the calcium level can result in a myriad of physiological responses, most of which are mediated by calmodulin. Calmodulin (CaM), a 148-amino acid universal calcium sensor, directly modulates the activity of protein kinases and phosphatases, ion channels and nitric oxide synthetases. Approximately 15% of CaM in the cell is phosphorylated and this phospho-rylation is mediated by casein kinase II on Thr 79, Ser 81, Ser 101 and Thr 117. Although CaM is constitutively phosphorylated, insulin increases phosphate incorporation into serine, threonine and tyrosine residues in intact cells. Phosphocalmodulin (p-CaM) exhibits altered biological activity. For example, p-CaM reduces activation of the erythrocyte plasma membrane Ca2+ pump. This strongly suggests that phosphorylation of CaM is an important component of intracellular signaling.