p-TGFβ RII (Tyr 424)-R Antibody: sc-17007-R

TGFβ RII Background Information
A total of three members of the TGF∫ family, TGF∫1, TGF∫2 and TGF∫3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGF∫s mediate their activity by high affinity binding to the type II receptor (TGF∫ RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. TGF∫ RII (TGF-beta receptor type-2), also known as TGFBR2, is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain and is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. For signaling growth inhibition and early gene responses, TGF∫ RII requires both its kinase activity and association with a TGF∫-binding protein, designated the type I receptor. TGF∫ RII exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 3.