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- rabbit polyclonal IgG, 200 µg/ml; also available as goat IgG, 200 µg/ml, sc-170-G
- epitope mapping at the C-terminus of Cbl of human origin
- recommended for detection of normal and rearranged forms of Cbl of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-170 P
- agarose conjugate for IP studies, sc-170 AC, 500 µg/0.25 ml agarose
- fluorescein (sc-170 FITC) and rhodamine (sc-170 TRITC) conjugates for immunofluorescence, 200 µg/ml
- Alexa Fluor® 405 (sc-170 AF405), Alexa Fluor® 488 (sc-170 AF488) and Alexa Fluor® 647 (sc-170 AF647) conjugates for immunofluorescence; 100 µg/2 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CBL |
867 |
11q23.3 |
NM_005188 |
P22681
|
165360 |
| Mouse |
Cbl |
12402 |
9 A5.1 |
|
P22682
|
N/A |
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Cbl Background Information
Cbl (also designated the c-Cbl proto-oncogene, E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, and RING finger protein 55) has been identified as the cellular homolog of the v-Cbl oncogene isolated from an NFS/N mouse that developed a pre-B cell lymphoma following infection with the replication-competent Cas Br-M murine leukemic virus. c-Cbl is expressed at relatively high levels in a wide range of hematopoietic tumor cell lines as well as in normal tissues such as thymus and testis. The c-Cbl gene product has been identified as a cytoplasmic protein with apparent DNA binding and dimerization domains characteristic of transcription factors. A single c-Cbl locus termed CBL2 has been mapped to human chromosome 11q23. This region of chromosome 11 is involved in translocations and deletions in a broad range of leukemias; c-Cbl has been found to be translocated from chromosome 11 in leukemias with either t(4;11) or t(11;14) abnormalities.
******Background shortened to fit on datasheet, per Susan*******
| Cbl (C-15) Product Citations |
See how others have used Cbl (C-15): sc-170 antibody and or Cbl (C-15) antibody conjugates.
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Cbl (C-15)
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Cbl (C-15): sc-170. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
Cbl (C-15): sc-170. Western blot analysis of Cbl p120 expression in K-562 (A), 3611-RF (B) and SK-BR-3 (C) whole cell lysates.
Cbl (C-15): sc-170. Western blot analysis of Cbl expression in 3T3-L1 (A), NIH/3T3 (B) and IB4 (C) whole cell lysates.
Cbl (C-15): sc-170. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.
Cbl (C-15)-G: sc-170-G. Western blot analysis of Cbl expression in K-562 whole cell lysate. Cbl (C-15): sc-170. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic staining of cells in seminiferous ducts.
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